Determination of Thermodynamic Protonation Constants of Some Selective Serotonin Reuptake Inhibitors in Water-Acetonitrile Binary Mixtures

Determination of Protonation Constants of Some Tetracycline Antibiotics by Potentiometry and LC Methods in Water and Acetonitrile-Water Binary Mixtures

Uma estimativa acurada das constantes de dissociação de antibióticos tetraciclina em misturas binárias acetonitrila-água é muito importante para muitas técnicas de separação, como cromatografia líquida e eletroforese capilar que usam essas misturas de solvente. Neste estudo, os valores de pK a de cinco tetraciclinas (tetraciclina, oxitetraciclina, clorotetraciclina, doxiciclina e metaciclina) f...

Spectrophotometric determination of acidity constants of some macrolides in acetonitrile-water binary mixtures.

The acidity constants of eight macrolides (erythromycin, roxithromycin, oleandomycin, azithromycin, josamycin, tylosin tartrate, tilmicosin and spiramycin) have been determined in acetonitrile-water binary mixtures (30%, 40% and 50% (v/v)) by spectrophotometric method. The pKa's available in literature determined by various methods are compiled in comparison with the value of this work. These r...

The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures

The protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic strength. The influence of cavity size, location of protonation sites, and attached substituents of...

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors.